Endocrine Abstracts

Serum testosterone level is known to inversely correlate with insulin sensitivity and obesity in men. Furthermore, there is evidence to suggest that testosterone replacement therapy reduces insulin resistance and visceral adiposity in Type 2 diabetic men. Adipocytokines are hormones secreted by adipose tissue and contribute to insulin resistance. We report a double-blind placebo controlled crossover study in 20 hypogonadal Type 2 diabetic men examining the effect of testostero...

Background: The function of the thyroid gland effects on obesity and comorbidities. It has been proven for bariatric surgery to be the most effective in obesity treatment.Aim: To evaluate the dynamics of body weight, thyroid status, leptin and insulin resistance in obese patients after bariatric surgery.Materials and methods: 78 obese patients were observed after bariatric surgery (sleeve gastrectomy – 46, gastric bypass &#82...

OBJECTIVE: To investigate the association between APD, treated Cushing's disease and severe hypopituitarism.METHODS: Fifty-seven patients (42 female), in remission after treatment for Cushing's disease, were studied. The cohort comprised 13 patients with, and 44 without APD. APD was defined as a serum prolactin persistently below the detection limit of the assay. Age and gender did not significantly differ between sub-groups.RESULT...

Introduction. As for many minor metabolites of steroids, no authentic standard is commercially available for 18-OH-THA. This compound is the principal urinary metabolite of 18-hydroxycorticosterone, a putative intermediate in the synthesis of aldosterone and of diagnostic value in screening for hypermineralocorticoidism. Since de novo synthesis is time-consuming and expensive, we tested the possibility of using beta-cortol, which produces an ion at m/z 457 in common wit...

Case presentations: Case 1: The index case is a 10 year old girl who presented episodic symptoms of feeling unwell, unexplained headache, seizure, vomiting and dehydration over a period of 8 months. She was subsequently found to have systemic hypertension which led to further investigations revealing raised plasma noradrenaline of 32 and 103.7 (NR 0–5 nmol/). US abdomen suggested bilateral pheochromocytoma but an MIBG showed unilateral left sided increased uptake. She und...

Pancreatic neuroendocrine tumors (panNETs) are the second most common neoplasm of the pancreas. panNETs arise from cells of the pancreatic islets and comprise a diverse and heterogeneous group of neoplasms. This hampers their systematic study, and the identification of common molecular signatures that might facilitate a better diagnosis of the disease, and the development of efficient therapeutic approaches. Indeed, there are no clinical, biochemical, anatomopathological, immu...

Background: Studies on thyroid hormones in obese adult patients are contradictory. Moreover, little is known about the effect of weight loss on thyroid functions. Thus, we aimed to investigate thyroid hormone status, and possible effect of weight loss on thyroid hormones in obese patients.Methods: We study population consisted of 39 (35 female, 4 male) euthyroid obese patients with mean age 42.76±10.52 years. Of these 19 patients were morbid obese. ...

While a number of studies have shown that treatment of children born small for gestational age (SGA) with continuously administered growth hormone (GH) induces a significant height improvement, this clinical trial approved by the local ethics committee investigated in a prospective way the growth response to different intermittent recombinant human GH (r-hGH, Saizen) treatment regimens over 4 years.Fifty-eight severely short (height standard deviation sc...

While a number of studies have shown that treatment of children born small for gestational age (SGA) with continuously administered growth hormone (GH) induces a significant height improvement, this clinical trial approved by the local ethics committee investigated in a prospective way the growth response to different intermittent recombinant human GH (r-hGH, Saizen) treatment regimens over 4 years.Fifty-eight severely short (height standard deviation sc...

A role for local corticosteroid metabolism by 11beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) has been proposed in bone and adipose tissue physiology. In vivo, 11b-HSD1 predominantly converts inactive cortisone to active cortisol and enzyme activity is critically dependent on substrate concentration. To examine 11b-HSD1 activity in vivo we have analysed the relationship between serum cortisone and markers of bone turnover, BMD and adipose tissue mass in a c...